No. HOKAMIX can temporarily give looser stools or more moulting. This is nothing to worry about. It just means that HOKAMIX is doing its job and all waste products present are discharged from the body.
For the rest no side effects are known. There are dogs who do not tolerate certain nutrients. In all the years HOKAMIX has been on the market, it rarely occurred that a dog did not tolerate HOKAMIX.